Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1β-induced apoptosis via the P13K/AKT signaling pathway

Hyperbaric Oxygen Therapy (HBOT), Osteoporosis & Degenerative Disc Disease

Mandibular condylar chondrocyte apoptosis is mainly responsible for the development and progression of temporomandibular joint osteoarthritis (TMJ-OA). Interleukin-1β (IL-1β) generally serves an agent that induces chondrocyte apoptosis. Hyperbaric oxygen (HBO) treatment increases proteoglycan synthesis in vivo.We explore the protective effect of HBO on IL-1β-induced mandibular condylar chondrocyte apoptosis in rats and the potential molecular mechanisms.…

Synergistic effects of HBO and PRP improve bone regeneration with autologous bone grafting

Hyperbaric Oxygen Therapy (HBOT), Osteoporosis & Degenerative Disc Disease

Bone defects remain a challenge for patients and orthopaedic surgeons. Autologous transfer of cancellous bone grafts remains the standard of care. However, in recent years various osteoinductive substitute materials, such as platelet rich plasma (PRP) and hyperbaric oxygen therapy (HBO) have been shown to improve bone healing. This study evaluates the effects of a combined…

Effects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in rats

Hyperbaric Oxygen Therapy (HBOT), Osteoporosis & Degenerative Disc Disease

Disuse-induced bone loss is caused by a suppression of osteoblastic bone formation and an increase in osteoclastic bone resorption. There are few data available for the effects of environmental conditions, i.e., atmospheric pressure and/or oxygen concentration, on osteoporosis. This study examined the effects of mild hyperbaric oxygen at 1317 hPa with 40% oxygen on unloading-induced…